Take care not to let your blood sugar get too low, which can be caused by stress, skipping meal, exercising too long, or drinking alcohol. In normal healthy volunteers, the intra-individual variabilities of Cmax, AUC, and CL for glimepiride were 23 17 and 15 respectively, and the inter-individual variabilities were 25 29 and 24 respectively. HOW TO USE: Take this medication by mouth usually once daily, with breakfast or the first main meal of the day. Do not change the dose of your medicine without checking with your doctor. To achieve the goal of treatment of AMARYL optimal control of blood glucose adherence to correct diet, regular and sufficient physical exercise and, if necessary, reduction of body weight are just as necessary glimepiride no physician approval as regular ingestion of AMARYL.