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Risk C: Monitor therapy Barbiturates: Primidone may enhance the adverse toxic effect of Barbiturates. Other pharmacological agents include alprazolam Xanax atenolol, sotalol, nadolol, clozapine, nimodipine, and botilinum toxin. At that time my Gastro was searching for some way to help my digestive tract to work properly. 22 Roman and Caratzali reported in 1971 that the offspring of mice treated with primidone primidone ohne rx had more abnormal bone metaphases than this was due to chromosomal lesions. Click Precautions and Warnings With Primidone to learn more, including information on who should not take the drug. To prevent pregnancy, use an extra form of birth control eg, condoms.