The study compared group of 6,828 patients who were concurrently taking PPI and clopidogrel to group of 9,862 patients who were only taking clopidogrel. Pantoprazole is well it undergoes little first-pass metabolism resulting in an absolute bioavailability of approximately 77. Antisecretory Activity Under maximal acid stimulatory conditions using pentagastrin, dose-dependent decrease in gastric acid output occurs after single dose of oral 20-80 mg or single dose of intravenous 20-120 mg pantoprazole in healthy volunteers. Therefore, it is expected that pantoprazole would not significantly affect the pharmacokinetics of other drugs metabolized by these isozymes. Ask your health care provider how to dispose of these materials protonix online billig after use. Multum drug information does not endorse drugs, diagnose patients or recommend therapy. These effects may be worse if you take it with alcohol or certain medicines.