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327 of the patients discontinued due to local skin application site reactions. Most GPs 95 issued as-needed prescriptions on 13 did this often. Clinical Trials Experience: Actinic Keratosis The data described below reflect exposure to Aldara Cream or vehicle in 436 subjects enrolled in apotheke aldara two double-blind, vehicle-controlled studies. Pharmacokinetics and safety were assessed after the first and last doses, as well as biweekly.