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These effects, along with diabetes, may increase your risk for developing heart disease. If rechallenged, monitor clozaril overdosis weekly for year before returning to the usual monitoring schedule of every weeks for months and then every weeks ad infinitum Severe Leukopenia Severe Granulocytopenia WBC 2000 mm and or ANC 1000 mm. In the multicenter study that provides primary support for the effectiveness of Clozaril in patients resistant to standard drug treatment for schizophrenia, patients were titrated during the first weeks up to maximum dose of 500 mg day, on.