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Adverse Reactions Summary Hematologic The most common side effect is bone marrow suppression. Women of childbearing potential should be advised to avoid becoming pregnant. Dose adjustment on the basis of blood counts at the nadir and day of treatment should be considered. Check the label on the medicine for exact dosing instructions. The areas under the plasma concentration-time curves AUC after oral administration averaged 61 26 standard deviation SD cheap alkeran online range 25 to 89 of those following IV administration. Over as short time as 30 minutes, citrate derivative of melphalan has been detected in reconstituted material from the reaction of ALKERAN with Sterile Diluent for ALKERAN. Experience with oral melphalan suggests that repeated courses should be given since improvement may continue slowly over many months, and the maximum benefit may be missed if treatment is abandoned prematurely.