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If you stop taking the medication, your condition could become worse. Children The safety and effectiveness of Isoptin in children under age 18 have not been established. Approximately 70 of an administered dose is excreted as metabolites in the urine and 16 or more in the feces within days. In multiple dose studies under fasting conditions the bioavailability measured by AUC of Isoptin SR was similar to ISOPTIN immediate rates of absorption were, of course, different. Upon discontinuation of ISOPTIN verapamil HCI the patient should isoptin sobredosis be reassessed to avoid underdigitalization.