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In your hands is the responsibility when you take this medication. In addition, 26 of oxcarbazepine-treated patients and 12 of placebo-treated patients experienced somnolence. The effect of these trileptal effecten interactions on mean AUCs and Cmin are summarized in Table. When Trileptal is administered as single 300-mg dose in renally-impaired patients creatinine clearance 30 mL min the elimination half-life of MHD is prolonged to 19 hours, with two-fold increase in AUC.