Although no treatment difference in change from baseline of ejection fractions was observed, more cardiovascular adverse events were observed with rosiglitazone treatment compared to placebo during the 52-week study see Table. There are multiple medications available to treat type diabetes. Total of 670 patients with type diabetes participated in two 26-week, randomized, double-blind, placebo active-controlled studies designed to assess the efficacy of rosiglitazone in combination with metformin. Your doctor should do blood tests to check your liver before you start taking AVANDAMET and during treatment as needed. When switching from combination therapy of rosiglitazone plus metformin as separate tablets, the kob avandamet online usual starting dose of AVANDAMET is the dose of rosiglitazone and metformin already being taken.